AChE/BChE-IN-27

Description

AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor Pe = 4.12 of AChE and BChE, with IC50 values of 3.72 ?M and 9.65 ?M, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC50 value of 6.32 ?M in the DPPH HY-112053 assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species ROS . In in vivo experiments, AChE/BChE-IN-27 effectively restored AChE and BChE levels, improved cognition, and can be used for Alzheimers disease AD .