GENERAL CATALOGUE
Adagrasib
HY-130149 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-130149
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Catalog No: HY-130149
CAS No: 2326521-71-3
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Adagrasib MRTX849 is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction.
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