GENERAL CATALOGUE
Adezmapimod hydrochloride
HY-10256A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-10256A
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medchemexpress.com/SB-203580-hydrochloride.html
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Catalog No: HY-10256A
CAS No: 869185-85-3
Category: Autophagy
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Adezmapimod SB 203580; RWJ 64809 hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38?2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3? and PKB? with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator.
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