GENERAL CATALOGUE
Adezmapimod (Standard)
HY-10256R · 5 mg
MedChemExpress · Cat: HY-10256R
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medchemexpress.com/adezmapimod-standard.html
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Catalog No: HY-10256R
CAS No: 152121-47-6
Category: Autophagy
Pack Size: 5 mg
Brand: MedChemExpress
Description
Adezmapimod Standard is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod SB 203580 is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38?2, respectively. Adezmapimod inhibits LCK, GSK3? and PKB? with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.
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