GENERAL CATALOGUE
AF615
HY-171180 · 5 mg
MedChemExpress · Cat: HY-171180
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Catalog No: HY-171180
CAS No: 122510-61-6
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex IC50 = 0.313 ?M . AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 ?M in case of Geminin-tCDT1 interaction and a Ki = 0.75 ?M in case of Geminin-miniCDT1 interaction.
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