GENERAL CATALOGUE
AFN-1252
HY-16911 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-16911
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Catalog No: HY-16911
CAS No: 620175-39-5
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ?0.015 ?g/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100 % protection from an otherwise lethal peritoneal infection of S. aureus Smith.
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