GENERAL CATALOGUE
AGI-14100
HY-120181 · 1 mg
MedChemExpress · Cat: HY-120181
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Manufacturer product page
medchemexpress.com/agi-14100.htmlCatalog No: HY-120181
CAS No: 1448346-43-7
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor IC50=6 nM . The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 mIDH1 inhibitors.
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