GENERAL CATALOGUE
AGI-41998
HY-145778 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145778
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Catalog No: HY-145778
CAS No: 2377492-26-5
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A MAT2A that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine SAM in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system CNS and colon cancer.
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