GENERAL CATALOGUE
AGI-43192
HY-145777 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145777
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Catalog No: HY-145777
CAS No: 2377491-54-6
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A MAT2A that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine SAM in HCT-116 MTAP-null cells with IC50s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system CNS and colon cancer.
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