GENERAL CATALOGUE
AJI-100
HY-164454 · 50 mg
MedChemExpress · Cat: HY-164454
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medchemexpress.com/aji-100.htmlCatalog No: HY-164454
CAS No: 844435-10-5
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease GVHD .
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