GENERAL CATALOGUE
AK-2292
HY-148813 · 1 mg
MedChemExpress · Cat: HY-148813
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medchemexpress.com/ak-2292.htmlCatalog No: HY-148813
CAS No: 2984506-77-4
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 ?M. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models. AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.
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