GENERAL CATALOGUE
AK-778-XXMU
HY-144707 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-144707
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medchemexpress.com/ak-778-xxmu.htmlCatalog No: HY-144707
CAS No: 1227045-76-2
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
AK-778-XXMU is a potent DNA binding inhibitor 2 ID2 antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors VEGFA and invasion-related proteins MMP2/9 , and up-regulating the tumor suppressor factor PTEN . AK-778-XXMU can be used for the study of glioma.
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