GENERAL CATALOGUE
Almonertinib hydrochloride
HY-112823B · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112823B
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medchemexpress.com/HS-10296_hydrochloride.html
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Catalog No: HY-112823B
CAS No: 2134096-03-8
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Almonertinib HS-10296 hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 IC50: 0.37, 0.29 and 0.21 nM, respectively , and is less effective against wild type 3.39 nM . Almonertinib hydrochloride is used for the research of the non-small cell lung cancer.
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