Alosetron (Hydrochloride(1:X))

Description

Alosetron GR 68755 Hydrochloride 1:X is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride 1:X is used for the research of irritable bowel syndrome IBS . Alosetron Hydrochloride 1:X blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at 55 nM. Alosetron Hydrochloride 1:X attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.