Alosetron ((Z)-2-butenedioate)

Description

Alosetron GR 68755 Z -2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Z -2-butenedioate is used for the research of irritable bowel syndrome IBS . Alosetron Z -2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at 55 nM. Alosetron Z -2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.