GENERAL CATALOGUE
Alsterpaullone
HY-108359 · 1 mg
MedChemExpress · Cat: HY-108359
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medchemexpress.com/alsterpaullone.htmlCatalog No: HY-108359
CAS No: 237430-03-4
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Alsterpaullone 9-Nitropaullone is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders. Alsterpaullone induces apoptosis in leukemia cell line.
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