GENERAL CATALOGUE
AM-0466
HY-135495 · 50 mg
MedChemExpress · Cat: HY-135495
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medchemexpress.com/am-0466.htmlCatalog No: HY-135495
CAS No: 1642113-59-4
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing.