GENERAL CATALOGUE
AM6545
HY-110206 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-110206
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Catalog No: HY-110206
CAS No: 1245626-05-4
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AM6545 is a highly selective, brain-free peripherally active CB1 receptor antagonist Ki=1.7 nM . AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment such as proteinuria, fibrosis and insulin resistance. AM6545 can be used in the study of obesity and its complications.
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