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AMG-1694
GENERAL CATALOGUE

AMG-1694

HY-12614 · 1 mg

MedChemExpress · Cat: HY-12614

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medchemexpress.com/amg-1694.html
Catalog No: HY-12614
CAS No: 1361217-07-3
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress

Description

AMG-1694 is a potent glucokinaseAAasAasAaglucokinase regulatory protein GK-GKRP disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.

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