GENERAL CATALOGUE
AMG-548 dihydrochloride
HY-108642B · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-108642B
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Catalog No: HY-108642B
CAS No: 2518299-32-4
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AMG-548 dihydrochloride, an orally active and selective p38? inhibitor Ki=0.5 nM , shows slightly selective over p38? Ki=36 nM and >1000 fold selective against p38? and p38?. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNF? IC50=3 nM . AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms ? and ?.
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