GENERAL CATALOGUE
AMG-548
HY-108642 · 1 mg
MedChemExpress · Cat: HY-108642
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medchemexpress.com/amg-548.htmlCatalog No: HY-108642
CAS No: 864249-60-5
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
AMG-548, an orally active and selective p38? inhibitor Ki=0.5 nM , shows slightly selective over p38? Ki=36 nM and >1000 fold selective against p38? and p38?. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNF? IC50=3 nM . AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms ? and ?.
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