GENERAL CATALOGUE
AMG410
HY-173632 · 1 mg
MedChemExpress · Cat: HY-173632
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medchemexpress.com/amg410.htmlCatalog No: HY-173632
CAS No: 3040175-17-2
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP on - and GDP off -state inhibitor Kd GDP-state of 1 nM; Kd GTP-state of 22 nM . AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers.