GENERAL CATALOGUE
AMIGO2, His, Human
Z05017 · 100 ug
GenScript · Cat: Z05017
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genscript.com/protein/Z05017-AMIGO2_His_Human.html
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Catalog No: Z05017
Category: protein
Pack Size: 100 ug
Brand: GenScript
Description
Bromodomain and extraterminal domain inhibitors BETi represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.
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