Amitriptyline-d3 hydrochloride

Description

Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline hydrochloride . Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter SERT and noradrenaline reuptake transporter NET , with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter DAT with a Ki of 2.58 ?M. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.