GENERAL CATALOGUE
AMZ30
HY-12833 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-12833
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Catalog No: HY-12833
CAS No: 1313613-09-0
Category: MAPK ERK Pathway
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
AMZ30 is selective protein phosphatase methylesterase-1 PME-1 inhibitor with IC50s of 600 nM and 3.5 AAasAasAAmuM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma.
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