Anagrelide-13C2,15N,d2

Description

Anagrelide-13C2,15N,d2 is 15N and deuterated labeled Anagrelide HY-B0523 . Anagrelide is a potent inhibitor of phosphodiesterase type III PDE3 IC50=36 nM . Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor GIST cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action.