GENERAL CATALOGUE
And1-IN-1
HY-150184 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-150184
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medchemexpress.com/and1-in-1.htmlCatalog No: HY-150184
CAS No: 2451028-69-4
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 ?M. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer.