Angelicin

Description

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-?B and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of ?-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression IC50=28.95 ?M . Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-?B, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.