Anti-ABCB1 Antibody

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette ABC transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. provided by RefSeq, Jul 2008