Anti-CLOCK Antibody

Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix bHLH family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL BMAL1 that binds E-box enhancer elements upstream of Period PER1, PER2, PER3 and Cryptochrome CRY1, CRY2 genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2014