Anti-DUSP7 Antibody

Description

Dual-specificity phosphatases DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK mitogen-activated protein kinase proteins ERK see MIM 601795 , JNK see MIM 601158 , and p38 see MIM 600289 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 see MIM 116947 -like CH2 domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses summary by Patterson et al., 2009 PubMed 19228121 . supplied by OMIM, Dec 2009