Anti-Human LPP3 Antibody

Description

Lipid phosphate phosphohydrolase 3 LPP3 , also known as phospholipid phosphatase 3 PLPP3 and phosphatidic acid phosphatase type 2B PAP-2b or PPAP2B , is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid LPA and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects. The PPAP2B gene also contains one of 27 loci associated with increased risk of coronary artery disease.