Anti Human STARD5 Polyclonal Antibody

Description

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element SRE -binding proteins e.g., SREBP1; MIM 184756 and by liver X receptors e.g., LXRA; MIM 602423 . Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein STAR; MIM 600617 . STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer START domain, including STARD5 Soccio et al., 2002 PubMed 12011452 . supplied by OMIM, Mar 2008