Anti-MRSA agent 26

Description

Anti-MRSA agent 26 is a potent anti-MRSA agent with MIC 0.015 ?g/mL. Anti-MRSA agent 26 has superior activity against a broad range of Gram-positive pathogens and shows no cytotoxicity in three mammalian cell lines Caco-2, DU-145 and MDCKII MDR1 cells at 10 ?M. Anti-MRSA agent 26 has a robust TAP pharmacophore and an excellent antibacterial activity in Staphylococcus aureus skin infection mice model.