Anti-RAR alpha Antibody

Description

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor RAR and retinoid X receptor RXR; see MIM 180245 , which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 MIM 600849 , SMRT NCOR2; MIM 600848 , and histone deacetylase see MIM 601241 . When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases see MIM 603053 , and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia APL; MIM 612376 . The most frequent translocation is t 15,17 q21;q22 , which fuses the RARA gene with the PML gene MIM 102578 Vitoux et al., 2007 PubMed 17468032 .