anti-TNBC agent-8

Description

anti-TNBC agent-8 Compound TP2 is a photodynamic therapeutic agent targeting mitochondrial DNA G4 mtG4 . Under white light irradiation, its IC50 against 4T1 cells is 0.42 ?M. anti-TNBC agent-8 binds tightly to mtG4 and generates a large amount of reactive oxygen species ROS under white light irradiation, leading to the loss of mitochondrial membrane potential MMP , a decrease in ATP production, and an increase in the ROS level. This, in turn, induces significant apoptosis in triple-negative breast cancer TNBC cells, exerting the activity of inhibiting tumor cell growth. anti-TNBC agent-8 can be used in the research of triple-negative breast cancer.