Antibacterial agent 106

Description

Antibacterial agent 106 compound 8 is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant MDR -Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7 % of the intracellular methicillin-resistant S. aureus MRSA harbored inside macrophages. Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.