Antibacterial agent 256

Description

Antibacterial agent 256 Compound C09 is an inhibitor for type I signal peptidase SPase I . Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 ?g/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 ?g/mL and 21.93 ?g/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 ?g/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model.