Antibacterial agent 272

Description

Antibacterial agent 272 Compound Z22 is a potential antimicrobial agent targeting DNA and the DNA-topoisomerase II DNA-Topo II complex, exhibiting MIC values of 1 ?g/mL against Staphylococcus aureus 25923 and 29213, 2 ?g/mL against Staphylococcus epidermidis 12228, 2-4 ?g/mL against Enterococcus faecalis, and 4 ?g/mL against Pseudomonas aeruginosa 9027 and 27853, demonstrating potent antibacterial activity. This compound functions by intercalating with DNA base pairs to disrupt normal bacterial DNA function, making it suitable for research on bacterial infectious diseases.