Antibacterial agent 274

Description

Antibacterial agent 274 Compound 18b is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 ?g/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections.