Antibacterial agent 284

Description

Antibacterial agent 284 Compound 7 is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA IC50: 0.96 ?M with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin ProA substrates and reduces immune evasion from the TLR5-NF-?B pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires disease research.