Antifolate C2

Description

Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer NS-NSCLC . Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter PCFT , which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed HY-10820 . Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase GARFTase , ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed.