Antifungal agent 130

Description

Antifungal agent 130 Compound A7 is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans MIC = 0.12 ng/mL and Cryptococcus neoformans MIC = 0.12 ng/mL and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors such as biofilm, capsule, urease and melanin . Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections.