Antileishmanial agent-22

Description

Antileishmanial agent-22 compound 15b is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial IC50=0.408 ?M based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 ?M with inhibitory rates of 88 % and 94 %, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67 % suppression under 48.4 ?M/kg/day and 0.038 ?M IC50 , respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 ?M.