Antimicrobial agent-34

Description

Antimicrobial agent-34 compound 4h is an antibacterial agent MIC = 1AAasAasAa4 ?g/mL , with a clogP value of 9.14. Antimicrobial agent-34 has good plasma stability HC50 of 131.1 ?g/mL and good membrane selectivity HC50/MIC is 65.6 , with rapid sterilization capability. Antimicrobial agent-34 destroys the integrity of bacterial cell membranes, induces an increase in intracellular reactive oxygen species, and leaks protein and DNA, ultimately leading to bacterial death. Antimicrobial agent-34 demonstrates significant in vivo antibacterial potency in a mouse sepsis model infected with Staphylococcus aureus ATCC43300.