Antiparasitic agent-26

Description

Antiparasitic agent-26 Compound 8 is an antiparasitic compound that potently inhibits the growth of Naegleria fowleri, with IC50 values of 22.87 ?M trophozoite stage and 25.16 ?M cyst stage . Antiparasitic agent-26 exerts its antiparasitic activity by inducing programmed cell death, including cytoplasmic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be used in the research of primary amoebic meningoencephalitis PAM .