Antiproliferative agent-23

Description

Antiproliferative agent-23 is a microtubule-destabilizing agent MDA and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species ROS -mediated endoplasmic reticulum stress in A549/CDDP cells cisplatin resistant cancer cell line via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity.