GENERAL CATALOGUE
Antiproliferative agent-25
HY-155051 · 50 mg
MedChemExpress · Cat: HY-155051
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Catalog No: HY-155051
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Antiproliferative agent-25 Compound 3s4 is a selective PRMT5 inhibitor IC50: 0.11 ?M . Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes.
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