Antiproliferative agent-64

Description

Antiproliferative agent-64 Compound 76 is an inhibitor for eukaryotic translation initiation factor 4E eIF4E , that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5 untranslated region 5UTR of c-Myc c-myc 5UTR with an EC50 of 1.2 nM, inhibits 5UTR encoding tubulin tub 5UTR with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM.