GENERAL CATALOGUE
Antitumor agent-163
HY-163691 · 50 mg
MedChemExpress · Cat: HY-163691
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medchemexpress.com/antitumor-agent-163.html
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Catalog No: HY-163691
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
Antitumor agent-163 Compound 3 is a photosensitizer used in Molecular-Targeted Photodynamic Therapy MT-PDT targeting carbonic anhydrase IX CAIX . Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as ?-tubulin, ?-actin, and proliferating cell nuclear antigen PCNA . Antitumor agent-163 induces cell membrane damage, inhibits cell viability IC50 is 0.2 and 0.05 ?M for A549 and U87MG . Antitumor agent-163 exhibits antitumor efficacy in mouse model.
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